Hazard Ratio Calculator
The Hazard Ratio Calculator computes the ratio of hazard rates between two groups in survival analysis. Interpret hazard ratios from clinical trials, Kaplan-Meier curves, and Cox proportional hazards models for treatment effectiveness.
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What is a Hazard Ratio?
A hazard ratio (HR) compares the instantaneous rate of an event (death, disease recurrence, failure) between two groups at any point in time. An HR of 0.70 means the treatment group has 30% lower hazard (risk at any given moment) than the control group throughout the study period.
Hazard ratios are derived from Cox proportional hazards regression and are the standard measure in survival analysis. Unlike relative risk (which compares cumulative probabilities), HR compares instantaneous rates and handles censored data (patients lost to follow-up).
使用される計算公式・方程式
この計算ツールは5つの主要な公式を使用しています：
1 Hazard Ratio ▼
HR < 1 favors treatment. HR > 1 favors control. HR = 1 means no difference.
2 Median Survival Ratio (approximation) ▼
If HR = 0.5, the treatment group lives approximately twice as long (median survival ratio = 2).
3 Risk Reduction from HR ▼
HR = 0.65: Risk reduction = (1-0.65) × 100 = 35% reduction in the event rate.
比率計算ツールの使い方
この比率計算ツールは、以下の3ステップで簡単にご利用いただけます：
数値を入力
入力欄に既知の比率の値を入力します。求めたい未知数の入力欄は空欄のままにしておきます。
モードを選択
比率モード（解く、簡素化、スケーリング）を選択します。各モードで異なる計算式が適用されます。
結果を確認
計算するボタンを押します。結果画面に答えと、視覚的な比率バー、円グラフ、詳細なステップバイステップの解決プロセスが表示されます。
実例問題と段階的な解説
本比率計算ツールを使って、以下の3つの例題をステップバイステップで解決するプロセスです：
入力 1 Cancer trial: HR = 0.72 for new drug
入力 2 Compare two treatments: HR = 1.15
入力 3 Estimate median survival improvement
よくある質問 (FAQ)
What does a hazard ratio of 0.5 mean? ▼
HR = 0.5 means the treatment group has half the instantaneous risk of the event at any time point compared to the control group. This represents a 50% risk reduction and roughly doubles the time-to-event.
How is hazard ratio different from relative risk? ▼
Relative risk compares cumulative event probabilities over the entire study. Hazard ratio compares instantaneous event rates at any point in time. HR handles censored data and time-varying exposure, while RR cannot.
When is a hazard ratio statistically significant? ▼
When its 95% confidence interval does not include 1.0. HR = 0.70 with CI (0.50, 0.98) is significant. HR = 0.70 with CI (0.45, 1.10) is not significant because the CI crosses 1.0.
What is the proportional hazards assumption? ▼
Cox regression assumes the HR remains constant over time. If the treatment is very effective early but less so later, the proportional hazards assumption is violated. Schoenfeld residuals test this assumption.
Can hazard ratio be used with Kaplan-Meier curves? ▼
HR is typically derived from Cox regression, not directly from Kaplan-Meier curves. However, the log-rank test p-value from KM analysis can assess significance, and HR provides the effect size.