Hazard Ratio Calculator
The Hazard Ratio Calculator computes the ratio of hazard rates between two groups in survival analysis. Interpret hazard ratios from clinical trials, Kaplan-Meier curves, and Cox proportional hazards models for treatment effectiveness.
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What is a Hazard Ratio?
A hazard ratio (HR) compares the instantaneous rate of an event (death, disease recurrence, failure) between two groups at any point in time. An HR of 0.70 means the treatment group has 30% lower hazard (risk at any given moment) than the control group throughout the study period.
Hazard ratios are derived from Cox proportional hazards regression and are the standard measure in survival analysis. Unlike relative risk (which compares cumulative probabilities), HR compares instantaneous rates and handles censored data (patients lost to follow-up).
적용 수학 공식 및 방정식
이 Hazard Ratio Calculator는 5가지 핵심 수학 공식을 사용합니다:
1 Hazard Ratio ▼
HR < 1 favors treatment. HR > 1 favors control. HR = 1 means no difference.
2 Median Survival Ratio (approximation) ▼
If HR = 0.5, the treatment group lives approximately twice as long (median survival ratio = 2).
3 Risk Reduction from HR ▼
HR = 0.65: Risk reduction = (1-0.65) × 100 = 35% reduction in the event rate.
비율 계산기 사용법
이 비율 계산기는 아래의 3단계로 쉽게 사용할 수 있습니다:
수치 입력하기
입력 칸에 알고 있는 비율 값을 입력합니다. 구하려는 미지수 자리의 칸 하나는 비워둡니다.
모드 선택하기
비율 모드(풀기, 간소화, 스케일링)를 선택합니다. 각 모드는 입력한 수치에 맞춰 다른 공식들을 적용합니다.
결과 확인하기
계산하기 버튼을 누릅니다. 결과 화면에 정답과 함께 시각적인 비율 바, 원형 차트, 상세한 단계별 풀이 과정이 출력됩니다.
실제 예제 문제 및 단계별 풀이
비율 계산기를 활용하여 아래 3가지 예제 문제를 단계별로 해결하는 과정입니다:
입력 1 Cancer trial: HR = 0.72 for new drug
입력 2 Compare two treatments: HR = 1.15
입력 3 Estimate median survival improvement
자주 묻는 질문 (FAQ)
What does a hazard ratio of 0.5 mean? ▼
HR = 0.5 means the treatment group has half the instantaneous risk of the event at any time point compared to the control group. This represents a 50% risk reduction and roughly doubles the time-to-event.
How is hazard ratio different from relative risk? ▼
Relative risk compares cumulative event probabilities over the entire study. Hazard ratio compares instantaneous event rates at any point in time. HR handles censored data and time-varying exposure, while RR cannot.
When is a hazard ratio statistically significant? ▼
When its 95% confidence interval does not include 1.0. HR = 0.70 with CI (0.50, 0.98) is significant. HR = 0.70 with CI (0.45, 1.10) is not significant because the CI crosses 1.0.
What is the proportional hazards assumption? ▼
Cox regression assumes the HR remains constant over time. If the treatment is very effective early but less so later, the proportional hazards assumption is violated. Schoenfeld residuals test this assumption.
Can hazard ratio be used with Kaplan-Meier curves? ▼
HR is typically derived from Cox regression, not directly from Kaplan-Meier curves. However, the log-rank test p-value from KM analysis can assess significance, and HR provides the effect size.